302 Implications of the Paternal Environment for Future Generations
نویسندگان
چکیده
Abstract The use of genetically superior males for artificial insemination has arguably been the most important tool to maximize dissemination desirable genes and improve performance traits agriculturally species. sire’s reproductive fitness traditionally focuses on breeding soundness, with narrow assumption that role male is restricted providing sperm oocyte, such once fertilization occurs, gestational outcome depends entirely dam. role, however, extends beyond as epigenome mediates early embryo gene expression, thereby influencing subsequent quality developmental competence. Since sensitive environment, including nutrition, we used a rodent model paternal exposures test hypothesis multigenerational effects are transmitted through lineage. We also demonstrate possible mechanism transmission environmental information via epigenome. These findings should inspire animal industry increase their consideration environment in context optimizing productivity. (This research was funded by CIHR, FRQNT NSERC.)
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ژورنال
عنوان ژورنال: Journal of Animal Science
سال: 2022
ISSN: ['0021-8812', '1525-3163', '1525-3015', '1544-7847']
DOI: https://doi.org/10.1093/jas/skac247.267